Autistic Children More Likely To Have Handwriting Problems
Wednesday, November 11, 2009

A new study reveals that Autistic children are more likely to have problems in handwriting than those without autism. The study was conducted by researchers at the Kennedy Krieger Institute. Handwriting samples, motor skills, and visuospatial abilities of children were compared with autism spectrum disorders to typically developing children. The researchers found that handwriting of children with ASD was worse than that of typically developing children. Particularly, children with ASD had trouble forming letters. In other categories like size, alignment, and spacing, their handwriting was comparable to that of typically developing children. Parents of children with ASD are often the first ones to examine their children’s poor handwriting quality. This finding recognises fine motor control as a core source of the problem and reveals that children with ASD may not have difficulties across all domains. By identifying handwriting as a valid impairment, parents, teachers and therapists will now be able to follow techniques that will improve children’s handwriting. "The ability to keep up in classes and convey ideas through handwriting is fundamental to life," said Christina Fuentes, lead study author and researcher at the Kennedy Krieger Institute. "Knowing the causes of impairment allows us to strategically identify techniques that will help children with ASD improve their handwriting”. “Our study suggests that teaching children how to form letters, in combination with general training of fine motor control through techniques that include stabilizing the arm and the use of proper writing utensils, may be the best direction for improving handwriting performance," Fuentes added. The study has been published in the journal, Neurology.

Posted bySaini at 6:38 AM 0 comments  

Labels:

Gonorrhea Medication Might Help Fight Cancer
Sunday, November 8, 2009

Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease. The newest surprise discovered by researchers at the Johns Hopkins University School of Medicine is a gonorrhea medication that might help battle cancer. "Often times we are surprised that a drug known to do something else has another hidden property," says Jun Liu, Ph.D., a professor of pharmacology and molecular sciences at Johns Hopkins and author on the study published Oct. 1 in the Proceedings of the National Academy of Sciences. In this case, the surprise is a big one. The drug, acriflavine, used in the 1930s for treating gonorrhea, has turned out to have the previously unknown ability to halt the growth of new blood vessels. Preliminary tests showed that mice engineered to develop cancer had no tumor growth if treated with daily injections of acriflavine. Acriflavine stops blood vessel growth by inhibiting the function of the protein hypoxia-inducible factor (HIF)-1, which was discovered by Semenza's team in 1992. When HIF-1 senses that the surrounding environment is low in oxygen, it turns on genes necessary for building new vessels. Though essential for normal tissue growth and wound healing, HIF-1 is also turned on by cancers to obtain the oxygen they need to survive. Most importantly, in order for HIF-1 to work, two subunits must bind together like puzzle pieces. Most drugs are unable to prevent protein binding because the drug molecules can be much smaller than the proteins they interact with. A medicine must hit just the right spot, a critical domain or pocket on the surface of one protein to stop it from binding to another protein. Even though drugs that stop binding are uncommon, they are such an effective means to stop protein function that Semenza decided to look for one that might block HIF-1. To do that, he turned to the Johns Hopkins Drug Library, a collection of FDA- and internationally approved compounds in that was assembled by Liu. To visualize protein binding, scientists engineered a cell line so that when the HIF-1 subunits came together, they would cause the cell to light up like a firefly. They then tested each of the more than 3,000 drugs in the drug library in hopes of finding one that would turn out the light. Acriflavine did, andfurther studies confirmed that it was binding directly to HIF-1. Liu hopes that acriflavine can one day be incorporated into chemotherapy cocktails, one drug among many that help fight cancer. Hopkins is seeking even more new uses for old drugs. So far, drugs in the library have been screened for use against malaria, uberculosis, HIV and the Ebola virus. In the future, Liu expects even more researchers to take advantage of the library, which is continuing to grow as more drugs are added to the collection. "In the public domain, Hopkins has the largest drug library," says Liu. "The more drugs you have, the more possibilities, the higher the chance you rediscover something that will help." This study was funded by the Johns Hopkins Institute for Cell Engineering and the Foundation for Advanced Research in the Medical Sciences. So keep visiting.

Posted bySaini at 5:14 PM 0 comments  

Labels:

Subscribe to: Posts (Atom)